SkinCeuticals P-TIOX 30ml

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Expression lines
Forehead lines
Frown lines
Crow’s feet
Fine lines
Early visible signs of ageing
Uneven skin texture
Dull skin
Loss of radiance
Clients seeking a peptide serum
Clients seeking a non-retinol age-management serum
Normal, dry, oily and combination skin
Sensitive skin when introduced carefully

Helps visibly soften expression and contraction lines
Targets the appearance of nine common types of facial lines
Helps improve forehead, eye-area and lower-face line appearance
Supports smoother-looking skin
Helps refine uneven skin texture
Promotes a more luminous, glass-skin appearance
Provides peptide-based age-management support
Contains 5% Niacinamide to support brightness and barrier quality
Contains 5% PHA for gentle surface renewal
Helps hydrate and visibly plump the skin
Suitable for all skin tones
Can complement professionally administered anti-wrinkle treatment routines
Fragrance-free and dye-free

Use morning and evening on clean, dry skin.

Apply five to six drops across the forehead, cheeks and chin. Gently press or smooth the serum over the face, avoiding the immediate eye area.

Follow with eye care and moisturiser. During the day, finish with broad-spectrum SPF50+ sunscreen.

When layering with a vitamin C antioxidant serum, apply the vitamin C serum first, followed by P-TIOX.

Although SkinCeuticals indicates that P-TIOX can be used with retinol, clients who are sensitive to active ingredients may prefer to alternate the products initially.

Suggested Routine

AM: Cleanser → C E Ferulic → P-TIOX → Eye Cream → Moisturiser → SPF50+

PM: Cleanser → P-TIOX → Moisturiser

Advanced PM: Cleanser → Retinol → Moisturiser, alternating with P-TIOX nights if sensitivity develops

Advanced Peptide Complex

Combines two targeted peptides to help visibly soften expression lines and support smoother-looking skin.

Acetyl Hexapeptide-8

A cosmetic peptide used to help reduce the visible appearance of expression-related lines.

Dipeptide Diaminobutyroyl Benzylamide Diacetate

A synthetic peptide designed to complement the formula’s visible line-smoothing benefits.

5% Gluconolactone

A polyhydroxy acid or PHA that provides gentle exfoliating and humectant benefits, helping improve texture and radiance.

5% Niacinamide

Supports skin barrier quality, visible brightness, smoother texture and a more balanced-looking complexion.

Laminaria Digitata Extract

A brown algae extract providing conditioning, hydrating and antioxidant support.

Salicylic Acid

Provides complementary surface-refining and pore-supporting benefits. P-TIOX is not marketed as a dedicated salicylic-acid acne serum.

Glycerin

A humectant that helps attract moisture and maintain skin comfort.

Complete Australian Ingredient List

Aqua / Water / Eau, Niacinamide, Gluconolactone, Butylene Glycol, PEG/PPG/Polybutylene Glycol-8/5/3 Glycerin, Alcohol Denat., Pentylene Glycol, Methyl Gluceth-20, Glycerin, Potassium Hydroxide, Hydroxyethylcellulose, Salicylic Acid, Chlorphenesin, Phytic Acid, Adenosine, Sodium Benzoate, Laminaria Digitata Extract, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Acetyl Hexapeptide-8.

Ingredient lists may change. Clients should always check the ingredient list printed on their current Australian product packaging before use.

Clinical Information

In a manufacturer-sponsored cosmeto-clinical study involving 82 subjects using P-TIOX twice daily for 12 weeks, SkinCeuticals reports that the serum visibly reduced nine types of contraction lines by up to 20%.

The brand also reports increased skin radiance and a glass-skin appearance after one week, with visible age-management benefits maintained after three months of consistent use. The exact outcome can vary between individuals.

These findings are finished-product, manufacturer-reported cosmetic results. A peer-reviewed independent clinical trial of the complete retail formulation was not located during this review.

P-TIOX has also been physician-tested for use alongside professionally administered anti-wrinkle treatments. It should be described as complementary home skincare rather than an alternative to injectable or medical treatment.

Perfect Pairing

For expression lines and environmental protection:

C E Ferulic → P-TIOX → Triple Lipid Restore 2:4:2 → SPF50+

For expression lines and dehydration:

P-TIOX → HA Intensifier Multi-Glycan → Moisturiser

For advanced age management:

P-TIOX → A.G.E. Advanced Eye → A.G.E. Interrupter Advanced